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KMID : 0352419950140020132
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Keimyung Medical Journal
1995 Volume.14 No. 2 p.132 ~ p.136
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Effect of Estrogen/Progesterone on Bone Mass and Biochemical Markers of Bone Turnover in Postmenopausal Women
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Abstract
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A study in postmenopausal women was performed to assess the effect of treatment with estrogen/progesterone for twelve months on bone mineral density and bone biomarkers. Twenty-eight women with diagnosis of postmenopausal osteoporosis were
treated
with
estrogen/progesterone, and 1500mg/day calcium supplementation was given to all patients. After treatment with estrogen/progesterone for twelve months, a mild increase(+2.5%, P>0.05) of bone mineral density at the second lumbar vertebra was
obtained, and
serum osteocalcin and alkaline phosphatase bone isoenzyme values did not change after hormonal replacement treatment, but 24-hour urinary hydroxyproline/creatinine levels were reduced(P<0.05) significantly.
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KEYWORD
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